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Durham Research Online
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Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation.

Lopera, Alberto and Aguilar, Juan A. and Belda, Raquel and Verdejo, Begoña and Steed, Jonathan W. and García-España, Enrique (2020) 'Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation.', Soft matter., 16 (28). pp. 6514-6522.

Abstract

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP–polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1039/D0SM00704H
Date accepted:09 June 2020
Date deposited:06 August 2020
Date of first online publication:10 June 2020
Date first made open access:09 June 2021

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