Allen, A.M. and Neville, M.C. and Birtles, S. and Croset, V. and Treiber, C.D. and Waddell, S. and Goodwin, S.F. (2020) 'A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord.', eLife, 9 . e54074.
The Drosophila ventral nerve cord (VNC) receives and processes descending signals from the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory information from the periphery and sends ascending signals to the brain. We used single-cell transcriptomics to generate an unbiased classification of cellular diversity in the VNC of five-day old adult flies. We produced an atlas of 26,000 high-quality cells, representing more than 100 transcriptionally distinct cell types. The predominant gene signatures defining neuronal cell types reflect shared developmental histories based on the neuroblast from which cells were derived, as well as their birth order. The relative position of cells along the anterior-posterior axis could also be assigned using adult Hox gene expression. This single-cell transcriptional atlas of the adult fly VNC will be a valuable resource for future studies of neurodevelopment and behavior.
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|Publisher Web site:||https://elifesciences.org/articles/54074|
|Publisher statement:||Copyright Allen et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.|
|Date accepted:||03 April 2020|
|Date deposited:||21 August 2020|
|Date of first online publication:||21 April 2020|
|Date first made open access:||21 August 2020|
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