Skip to main content

Research Repository

Advanced Search

Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data

Allison, Timothy M.; Barran, Perdita; Benesch, Justin L.P.; Cianferani, Sarah; Degiacomi, Matteo T.; Gabelica, Valerie; Grandori, Rita; Marklund, Erik G.; Menneteau, Thomas; Migas, Lukasz G.; Politis, Argyris; Sharon, Michal; Sobott, Frank; Thalassinos, Konstantinos

Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data Thumbnail


Authors

Timothy M. Allison

Perdita Barran

Justin L.P. Benesch

Sarah Cianferani

Valerie Gabelica

Rita Grandori

Erik G. Marklund

Thomas Menneteau

Lukasz G. Migas

Argyris Politis

Michal Sharon

Frank Sobott

Konstantinos Thalassinos



Abstract

The past few years have seen a dramatic increase in applications of native mass and ion mobility spectrometry, especially for the study of proteins and protein complexes. This increase has been catalyzed by the availability of commercial instrumentation capable of carrying out such analyses. As in most fields, however, the software to process the data generated from new instrumentation lags behind. Recently, a number of research groups have started addressing this by developing software, but further improvements are still required in order to realize the full potential of the data sets generated. In this perspective, we describe practical aspects as well as challenges in processing native mass spectrometry (MS) and ion mobility-MS data sets and provide a brief overview of currently available tools. We then set out our vision of future developments that would bring the community together and lead to the development of a common platform to expedite future computational developments, provide standardized processing approaches, and serve as a location for the deposition of data for this emerging field. This perspective has been written by members of the European Cooperation in Science and Technology Action on Native MS and Related Methods for Structural Biology (EU COST Action BM1403) as an introduction to the software tools available in this area. It is intended to serve as an overview for newcomers and to stimulate discussions in the community on further developments in this field, rather than being an in-depth review. Our complementary perspective (http://dx.doi.org/10.1021/acs.analchem.9b05791) focuses on computational approaches used in this field.

Citation

Allison, T. M., Barran, P., Benesch, J. L., Cianferani, S., Degiacomi, M. T., Gabelica, V., …Thalassinos, K. (2020). Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data. Analytical Chemistry, 92(16), 10881-10890. https://doi.org/10.1021/acs.analchem.9b05792

Journal Article Type Article
Acceptance Date Jul 10, 2020
Online Publication Date Jul 10, 2020
Publication Date 2020-08
Deposit Date Aug 11, 2020
Publicly Available Date Jul 10, 2021
Journal Analytical Chemistry
Print ISSN 0003-2700
Electronic ISSN 1520-6882
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 92
Issue 16
Pages 10881-10890
DOI https://doi.org/10.1021/acs.analchem.9b05792

Files

Accepted Journal Article (2 Mb)
PDF

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical chemistry copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.9b05792





You might also like



Downloadable Citations