Recent advances in the development of anti-infective peptoids

Bicker, Kevin L.; Cobb, Steven L

doi:10.1039/d0cc04704j

Recent advances in the development of anti-infective peptoids

Bicker, Kevin L.; Cobb, Steven L

Authors

Kevin L. Bicker

Professor Steven Cobb s.l.cobb@durham.ac.uk
Professor

Abstract

In the search for new sources of antimicrobials many researchers have investigated antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics. However, efforts to develop AMPs in this area has been severely hampered by their inherent susceptibility to enzymatic degradation. Given this only a handful of AMPs are currently in clinical trials. Peptide mimetics such as peptoids have emerged as highly promising alternatives to AMPs as they are inherently stable to enzymatic degradation and display potent antimicrobial properties. This feature article highlights the progress that has been made towards the development of novel anti-infective peptoids.

Citation

Bicker, K. L., & Cobb, S. L. (2020). Recent advances in the development of anti-infective peptoids. Chemical Communications, 56(76), 11158-11168. https://doi.org/10.1039/d0cc04704j

Journal Article Type	Article
Acceptance Date	Aug 24, 2020
Online Publication Date	Aug 28, 2020
Publication Date	2020-09
Deposit Date	Oct 14, 2020
Publicly Available Date	Aug 28, 2021
Journal	Chemical Communications
Print ISSN	1359-7345
Electronic ISSN	1364-548X
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	56
Issue	76
Pages	11158-11168
DOI	https://doi.org/10.1039/d0cc04704j