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Designing magnesium-selective ligands using coordination chemistry principles.

Walter, Edward R.H. and Hogg, Christopher and Parker, David and Gareth Williams, J.A. (2021) 'Designing magnesium-selective ligands using coordination chemistry principles.', Coordination chemistry reviews., 428 . p. 213622.


Progress in the selective binding and detection of magnesium ions has been slower than other biologically important divalent metal ions like calcium and zinc. The most widely used ligands for Mg2+ are by no means optimal, as they are not selective for it. Nevertheless, Mg2+ is a major cation in all cells, with physiologically critical functions. There is a need for improved sensors for Mg2+. In this review, we consider how an appreciation of fundamental coordination chemistry principles may inform the development of new ligands for Mg2+. A number of representative examples of ligands of differing denticity are discussed in this context. Low-denticity ligands such as β-keto acids offer the best selectivities, but speciation is an issue as other polydentate ligands such as pyrophosphate may complete the coordination sphere. High-denticity ligands based on aminocarboxylates such as APTRA typically offer the highest stability constants, but they bind Ca2+ and Zn2+ more strongly than Mg2+. We highlight recent examples featuring related aminophosphinates, where the longer bonds and smaller bite angles favour selectivity towards Mg2+. Macrocyclic receptors for magnesium are not discussed explicitly.

Item Type:Article
Full text:Publisher-imposed embargo until 17 November 2021.
(AM) Accepted Manuscript
Available under License - Creative Commons Attribution Non-commercial No Derivatives.
File format - PDF
Publisher Web site:
Publisher statement:© 2020 This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Date accepted:21 September 2020
Date deposited:17 November 2020
Date of first online publication:17 November 2020
Date first made open access:17 November 2021

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