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Synthesis of complex unnatural fluorine-containing amino acids.

Brittain, William D.G. and Lloyd, Carissa M. and Cobb, Steven L. (2020) 'Synthesis of complex unnatural fluorine-containing amino acids.', Journal of fluorine chemistry., 239 . p. 109630.


The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid derivatives have grown, researchers have turned their attention to develop methodology to access complex proteinogenic examples. A variety of reaction conditions have been employed in this area, exploiting new advances in the wider synthetic community such as photocatalysis and palladium cross-coupling. In addition, novel fluorinated functional groups have also been incorporated into amino acids, with SFX and perfluoro moieties now appearing with more frequency in the literature. This review focuses on synthetic methodology for accessing complex non-proteinogenic amino acids, along with amino acids containing multiple fluorine atoms such as CF3, SF5 and perfluoroaromatic groups.

Item Type:Article
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Publisher statement:© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (
Date accepted:12 August 2020
Date deposited:18 November 2020
Date of first online publication:06 September 2020
Date first made open access:18 November 2020

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