Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications

Lloyd, Carissa M.; Colgin, Neil; Cobb, Steven L.

doi:10.3390/molecules25235601

Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications

Lloyd, Carissa M.; Colgin, Neil; Cobb, Steven L.

Authors

Carissa M. Lloyd

Neil Colgin

Professor Steven Cobb s.l.cobb@durham.ac.uk
Professor

Abstract

Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.

Citation

Lloyd, C. M., Colgin, N., & Cobb, S. L. (2020). Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications. Molecules, 25(23), Article 5601. https://doi.org/10.3390/molecules25235601

Journal Article Type	Article
Acceptance Date	Nov 24, 2020
Online Publication Date	Nov 28, 2020
Publication Date	2020-12
Deposit Date	Dec 1, 2020
Publicly Available Date	Dec 1, 2020
Journal	Molecules
Publisher	MDPI
Peer Reviewed	Peer Reviewed
Volume	25
Issue	23
Article Number	5601
DOI	https://doi.org/10.3390/molecules25235601

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