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Current synthetic routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and their applications.

Lloyd, Carissa M. and Colgin, Neil and Cobb, Steven L. (2020) 'Current synthetic routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and their applications.', Molecules., 25 (23). p. 5601.


Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.

Item Type:Article
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Publisher statement:© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Date accepted:24 November 2020
Date deposited:01 December 2020
Date of first online publication:28 November 2020
Date first made open access:01 December 2020

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