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Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system.

Craig, Peter S. and Dujardin, Bruno and Hart, Andy and Hernández‐Jerez, Antonio F. and Hougaard Bennekou, Susanne and Kneuer, Carsten and Ossendorp, Bernadette and Pedersen, Ragnor and Wolterink, Gerrit and Mohimont, Luc (2020) 'Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system.', EFSA journal., 18 (4). e06087.


A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations of the motor division. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system. Cumulative exposure assessments were conducted through probabilistic modelling by EFSA and the Dutch National Institute for Public Health and the Environment (RIVM) using two different software tools and reported separately. These exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual consumption data from 10 populations of consumers from different countries and different age groups. This report completes the characterisation of cumulative risk, taking account of the available data and the uncertainties involved. For each of the 10 populations, it is concluded with varying degrees of certainty that cumulative exposure to pesticides that have the acute effects on the nervous system mentioned above does not exceed the threshold for regulatory consideration established by risk managers.

Item Type:Article
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Publisher statement:© 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the Creative Commons Attribution‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
Date accepted:No date available
Date deposited:09 December 2020
Date of first online publication:29 April 2020
Date first made open access:09 December 2020

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