Skip to main content

Research Repository

Advanced Search

Reactivities of electrophilic N–F fluorinating reagents

Rozatian, Neshat; Hodgson, David R.W.

Reactivities of electrophilic N–F fluorinating reagents Thumbnail


Authors

Neshat Rozatian



Abstract

Electrophilic fluorination represents one of the most direct and useful methods available for the selective introduction of fluorine into organic compounds. Electrophilic fluorinating reagents of the N–F class have revolutionised the incorporation of fluorine atoms into both pharmaceutically- and agrochemically-important substrates. Since the earliest N–F reagents were commercialised in the 1990s, their reactivities have been investigated using qualitative and, more recently, quantitative methods. This review discusses the different experimental approaches employed to determine reactivities of N–F reagents, focussing on the kinetics studies reported in recent years. We make critical evaluations of the experimental approaches against each other, theoretical approaches, and their applicability towards practical problems. The opportunities for achieving more efficient synthetic electrophilic fluorination processes through kinetic understanding are highlighted.

Citation

Rozatian, N., & Hodgson, D. R. (2021). Reactivities of electrophilic N–F fluorinating reagents. Chemical Communications, 57(6), 683-712. https://doi.org/10.1039/d0cc06339h

Journal Article Type Article
Acceptance Date Dec 8, 2020
Online Publication Date Dec 24, 2020
Publication Date 2021
Deposit Date Jan 5, 2021
Publicly Available Date Dec 24, 2021
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 57
Issue 6
Pages 683-712
DOI https://doi.org/10.1039/d0cc06339h

Files





You might also like



Downloadable Citations