Guy S Bewick
Mechanotransduction channels in proprioceptive sensory nerve terminals: still an open question?
Bewick, Guy S; Banks, Robert W
Abstract
Mechanosensory transduction (MST) in proprioceptors, and other low threshold mechanosensory nerve terminals (LTMT), has been debated intensely for decades. MST in muscle spindles produces a receptor potential that encodes stimulus speed and duration, is predominantly due to Na+, a little Ca2+, plus some transient, non-mechanically-gated K+ ion fluxes. The abundant, multiple Na+-selective DEG/ENaC channel isoforms present in all LTMTs seemed obvious Na+ sources, perhaps supplemented with Ca2+-selective TRPs, and Ca2+-activated K+ channels. However, genetic deletions of even multiple DEG/ENaC genes produces only mild functional perturbation. Conversely, deleting the more recently discovered Piezo2 mechanosensory protein profoundly impairs LTMT responses, including in muscle spindles. Yet, its transient opening, non-Na+-selectivity and pharmacology do not reflect known receptor potential and response properties. A Ca2+-dependent recycling vesicle pool that we have shown is essential for mechanosensitivity, plus other recent DEG/ENaC discoveries, may reconcile these conflicting observations. We propose the abundance of axolemmal MST complexes, comprising untested DEG/ENaC combinations, is controlled by Piezo2-gated Ca2+ influx that regulates their vesicular insertion and retrieval.
Citation
Bewick, G. S., & Banks, R. W. (2021). Mechanotransduction channels in proprioceptive sensory nerve terminals: still an open question?. Current Opinion in Physiology, 20, 90-104. https://doi.org/10.1016/j.cophys.2020.11.007
Journal Article Type | Article |
---|---|
Online Publication Date | Dec 17, 2020 |
Publication Date | 2021-04 |
Deposit Date | Jan 20, 2021 |
Publicly Available Date | Dec 17, 2021 |
Journal | Current opinion in physiology. |
Print ISSN | 2468-8673 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 20 |
Pages | 90-104 |
DOI | https://doi.org/10.1016/j.cophys.2020.11.007 |
Keywords | Muscle spindle, low threshold mechanoreceptors, synaptic-like vesicle, Piezo, DEG/ENaC, transient receptor potential TRP |
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Copyright Statement
© 2021 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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