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Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial

Dabira, Edgard Diniba; Soumare, Harouna M; Lindsay, Steven W; Conteh, Bakary; Ceesay, Fatima; Bradley, John; Kositz, Christian; Broekhuizen, Henk; Kandeh, Balla; Fehr, Alexandra E; Nieto-Sanchez, Claudia; Ribera, Joan Muela; Peeters Grietens, Koen; Smit, Menno Roderick; Drakeley, Chris; Bousema, Teun; Achan, Jane; D’Alessandro, Umberto

Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial Thumbnail


Authors

Edgard Diniba Dabira

Harouna M Soumare

Bakary Conteh

Fatima Ceesay

John Bradley

Christian Kositz

Henk Broekhuizen

Balla Kandeh

Alexandra E Fehr

Claudia Nieto-Sanchez

Joan Muela Ribera

Koen Peeters Grietens

Menno Roderick Smit

Chris Drakeley

Teun Bousema

Jane Achan

Umberto D’Alessandro



Abstract

Background: With a decline in malaria burden, innovative interventions and tools are required to reduce malaria transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as a potential tool to further reduce malaria transmission, where coverage of vector control interventions is already high. However, the impact is limited in time. Combining an ACT with an endectocide treatment that is able to reduce vector survival, such as ivermectin (IVM), could increase the impact of MDA and offer a new tool to reduce malaria transmission. Objective: The study objective is to evaluate the impact of MDA with IVM plus dihydroartemisinin-piperaquine (DP) on malaria transmission in an area with high coverage of malaria control interventions. Methods: The study is a cluster randomized trial in the Upper River Region of The Gambia and included 32 villages (16 control and 16 intervention). A buffer zone of ~2 km was created around all intervention clusters. MDA with IVM plus DP was implemented in all intervention villages and the buffer zones; control villages received standard malaria interventions according to the Gambian National Malaria Control Program plans. Results: The MDA campaigns were carried out from August to October 2018 for the first year and from July to September 2019 for the second year. Statistical analysis will commence once the database is completed, cleaned, and locked. Conclusions: This is the first cluster randomized clinical trial of MDA with IVM plus DP. The results will provide evidence on the impact of MDA with IVM plus DP on malaria transmission.

Citation

Dabira, E. D., Soumare, H. M., Lindsay, S. W., Conteh, B., Ceesay, F., Bradley, J., …D’Alessandro, U. (2020). Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial. JMIR Research Protocols, 9(11), Article e20904. https://doi.org/10.2196/20904

Journal Article Type Article
Acceptance Date Jul 28, 2020
Online Publication Date Nov 19, 2020
Publication Date 2020-11
Deposit Date Mar 23, 2021
Publicly Available Date Mar 23, 2021
Journal JMIR Research Protocols
Publisher JMIR Publications
Peer Reviewed Peer Reviewed
Volume 9
Issue 11
Article Number e20904
DOI https://doi.org/10.2196/20904

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
©Edgard Diniba Dabira, Harouna M Soumare, Steven W Lindsay, Bakary Conteh, Fatima Ceesay, John Bradley, Christian Kositz, Henk Broekhuizen, Balla Kandeh, Alexandra E Fehr, Claudia Nieto-Sanchez, Joan Muela Ribera, Koen Peeters Grietens, Menno Roderick Smit, Chris Drakeley, Teun Bousema, Jane Achan, Umberto D’Alessandro. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 19.11.2020.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.





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