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Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development

Stuart-Walker, Will; Mahon, Clare S.

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Authors

Will Stuart-Walker



Abstract

Carbohydrate-based materials offer exciting opportunities for drug delivery. They present readily available, biocompatible components for the construction of macromolecular systems which can be loaded with cargo, and can enable targeting of a payload to particular cell types through carbohydrate recognition events established in biological systems. These systems can additionally be engineered to respond to environmental stimuli, enabling triggered release of payload, to encompass multiple modes of therapeutic action, or to simultaneously fulfil a secondary function such as enabling imaging of target tissue. Here, we will explore the use of glycomacromolecules to deliver therapeutic benefits to address key health challenges, and suggest future directions for development of next-generation systems.

Citation

Stuart-Walker, W., & Mahon, C. S. (2021). Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development. Advanced Drug Delivery Reviews, 171, 77-93. https://doi.org/10.1016/j.addr.2021.01.018

Journal Article Type Article
Acceptance Date Jan 23, 2021
Online Publication Date Feb 2, 2021
Publication Date 2021-04
Deposit Date Mar 31, 2021
Publicly Available Date Feb 2, 2022
Journal Advanced Drug Delivery Reviews
Print ISSN 0169-409X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 171
Pages 77-93
DOI https://doi.org/10.1016/j.addr.2021.01.018

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