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Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide

Saikia, Basanta; Mulvee, Matthew T.; Torres-Moya, Ivan; Sarma, Bipul; Steed, Jonathan W.

Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide Thumbnail


Authors

Basanta Saikia

Matthew T. Mulvee

Ivan Torres-Moya

Bipul Sarma



Abstract

A strategic approach to control the polymorphism of two related drugs by introducing a drug-mimetic imide functional group into the molecular weight organogelator structure is presented. This was achieved with novel aminoglutethimide-derived bis(urea) organogelators designed to form gels that act as targeted crystallization media for (±)-thalidomide and barbital. The organogelators prevent concomitant crystallization, a serious issue for drug formulation and development. This work demonstrates the potential to control concomitant crystallization with rationally designed supramolecular gelators.

Citation

Saikia, B., Mulvee, M. T., Torres-Moya, I., Sarma, B., & Steed, J. W. (2020). Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide. Crystal Growth and Design, 20(12), 7989-7996. https://doi.org/10.1021/acs.cgd.0c01240

Journal Article Type Article
Online Publication Date Nov 2, 2020
Publication Date 2020
Deposit Date Jun 3, 2021
Publicly Available Date Nov 2, 2021
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 20
Issue 12
Pages 7989-7996
DOI https://doi.org/10.1021/acs.cgd.0c01240

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Accepted Journal Article (920 Kb)
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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.0c01240





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