Saikia, Basanta and Mulvee, Matthew T. and Torres-Moya, Ivan and Sarma, Bipul and Steed, Jonathan W. (2020) 'Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide.', Crystal growth & design., 20 (12). pp. 7989-7996.
A strategic approach to control the polymorphism of two related drugs by introducing a drug-mimetic imide functional group into the molecular weight organogelator structure is presented. This was achieved with novel aminoglutethimide-derived bis(urea) organogelators designed to form gels that act as targeted crystallization media for (±)-thalidomide and barbital. The organogelators prevent concomitant crystallization, a serious issue for drug formulation and development. This work demonstrates the potential to control concomitant crystallization with rationally designed supramolecular gelators.
|Full text:||(AM) Accepted Manuscript|
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|Publisher Web site:||https://doi.org/10.1021/acs.cgd.0c01240|
|Publisher statement:||This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.0c01240|
|Date accepted:||No date available|
|Date deposited:||03 June 2021|
|Date of first online publication:||02 November 2020|
|Date first made open access:||02 November 2021|
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