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Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide

Saikia, Basanta and Mulvee, Matthew T. and Torres-Moya, Ivan and Sarma, Bipul and Steed, Jonathan W. (2020) 'Drug Mimetic Organogelators for the Control of Concomitant Crystallization of Barbital and Thalidomide.', Crystal growth & design., 20 (12). pp. 7989-7996.

Abstract

A strategic approach to control the polymorphism of two related drugs by introducing a drug-mimetic imide functional group into the molecular weight organogelator structure is presented. This was achieved with novel aminoglutethimide-derived bis(urea) organogelators designed to form gels that act as targeted crystallization media for (±)-thalidomide and barbital. The organogelators prevent concomitant crystallization, a serious issue for drug formulation and development. This work demonstrates the potential to control concomitant crystallization with rationally designed supramolecular gelators.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1021/acs.cgd.0c01240
Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.0c01240
Date accepted:No date available
Date deposited:03 June 2021
Date of first online publication:02 November 2020
Date first made open access:02 November 2021

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