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Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging

Zhang, Yonghong; Ma, Xia; Chau, Ho-Fai; Thor, Waygen; Jiang, Lijun; Zha, Shuai; Fok, Wan-Yiu; Mak, Ho-Nam; Zhang, Junhui; Cai, Jing; Ng, Chi-Fai; Li, Hongguang; Parker, David; Li, Li; Law, Ga-Lai; Wong, Ka-Leung

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging Thumbnail


Authors

Yonghong Zhang

Xia Ma

Ho-Fai Chau

Waygen Thor

Lijun Jiang

Shuai Zha

Wan-Yiu Fok

Ho-Nam Mak

Junhui Zhang

Jing Cai

Chi-Fai Ng

Hongguang Li

Li Li

Ga-Lai Law

Ka-Leung Wong



Abstract

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide–cyclen complexes (cycLn) with a well-known drug–camptothecin (CPT) through a redox-sensitive disulfide bond (−ss–). By accurately controlling the ratio of Gd(III) and Yb(III) complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CACs), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo have thus been achieved and validated. The work provides a blueprint combining a stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment.

Citation

Zhang, Y., Ma, X., Chau, H., Thor, W., Jiang, L., Zha, S., …Wong, K. (2021). Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging. ACS Applied Nano Material, 4(1), 271-278. https://doi.org/10.1021/acsanm.0c02597

Journal Article Type Article
Acceptance Date Dec 11, 2020
Online Publication Date Jan 4, 2021
Publication Date Jan 22, 2021
Deposit Date Jun 4, 2021
Publicly Available Date Mar 29, 2024
Journal ACS applied nano materials.
Electronic ISSN 2574-0970
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 4
Issue 1
Pages 271-278
DOI https://doi.org/10.1021/acsanm.0c02597

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Nano Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsanm.0c02597.




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