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No impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladesh

Chaney, C. and Begum, K. and Núñez-de la Mora, A. and Sievert, L. L. and Muttukrishna, S. and Harries, V. and Sharmeen, T. and Murphy, L. and Gunu, T. and Chowdhury, O. and Bentley, G. R. (2022) 'No impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladesh.', American journal of human biology, 34 (3). e23631.

Abstract

Introduction: While many aspects of female ovarian function respond to environmental stressors, estradiol (E2) appears less sensitive to stressors than progesterone, except under extreme ecological conditions. However, earlier studies relied on saliva samples, considered less sensitive than blood. Here, we investigated E2 variation among 177 Bangladeshi and UK white women, aged 35-59, using single serum samples. Bangladeshi women either grew up in Sylhet, Bangladesh (exposed to poor sanitation, limited health care, and higher pathogen loads but not poor energy availability), or in the UK. Methods: We collected samples on days 4-6 of the menstrual cycle in menstruating women and on any day for post-menopausal women. Participants included: i) Bangladeshi sedentees (n=36), ii) Bangladeshis who migrated to the UK as adults (n=52), iii) Bangladeshis who migrated as children (n=40), and iv) UK white women matched for neighborhood residence to the migrants (n=49). Serum was obtained by venipuncture and analyzed using electrochemiluminescence. We collected anthropometrics and supplementary sociodemographic and reproductive data through questionnaires. We analyzed the data using multivariate regression. Results: E2 levels did not differ between migrant groups after controlling for age, BMI, physical activity, psychosocial stress, parity, and time since last birth (parous women). Paralleling results from salivary E2, serum E2 did not differ among women who experienced varying developmental conditions. Conclusion: Our results reinforce the hypothesis that E2 levels are stable under challenging environmental conditions. Interpopulation variation may only arise under chronic conditions of extreme nutritional scarcity, energy expenditure, and/or high disease burdens.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1002/ajhb.23631
Publisher statement:This is the peer reviewed version of the following article: Chaney, C., Begum, K., Núñez-de la Mora, A., Sievert, L. L., Muttukrishna, S., Harries, V., Sharmeen, T., Murphy, L., Gunu, T., Chowdhury, O. & Bentley, G. R. (2022). No impact of developmental conditions on serum estradiol levels among Bangladeshi women in the UK and Bangladesh. American Journal of Human Biology 34(3): e23631, which has been published in final form at https://doi.org/10.1002/ajhb.23631. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
Date accepted:14 June 2021
Date deposited:17 June 2021
Date of first online publication:26 June 2021
Date first made open access:26 June 2022

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