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Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties

Gimenez, Diana and Phelan, Aoife and Murphy, Cormac D. and Cobb, Steven L. (2021) 'Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties.', Organic Letters, 23 (12). pp. 4672-4676.


Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.

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Date accepted:No date available
Date deposited:24 June 2021
Date of first online publication:02 June 2021
Date first made open access:24 June 2021

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