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Properties and Applications of Stimuli-Responsive Diacetylenes

Hall, Amy V. and Musa, Osama M. and Steed, Jonathan W. (2021) 'Properties and Applications of Stimuli-Responsive Diacetylenes.', Crystal growth & design., 21 (6). pp. 3614-3638.


The topochemical reactivity of diacetylene monomers has long been established and involves the 1,4-addition polymerization reaction. This reaction is governed by well-defined parameters that allow the synthesis of diacetylene polymers. Polydiacetylenes are conjugated polymers that display unique colorimetric and fluorescent transitions when they are exposed to a range of stimuli, allowing them to be easily exploited in biosensors, chemosensors, and radiochromic dosimeters. In this review, we summarize recent work on polydiacetylene systems, focusing on examples involving 10,12-pentacosadiynoic acid (PCDA) that can be structured as polymerized vesicles, films, gels, and powders. Synthetic derivatives of PCDA are also reviewed, along with the effect of incorporating guest molecules to a diacetylene system and establishing the important relationship between reversible thermochromism and noncovalent interactions.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Date accepted:No date available
Date deposited:29 July 2021
Date of first online publication:10 May 2021
Date first made open access:10 May 2022

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