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Targeted pH switched europium complexes monitoring receptor internalisation in living cells

Fradgley, Jack D. and Starck, Matthieu and Laget, Michel and Bourrier, Emmanuel and Dupuis, Elodie and Lamarque, Laurent and Trinquet, Eric and Zwier, Jurriaan M. and Parker, David (2021) 'Targeted pH switched europium complexes monitoring receptor internalisation in living cells.', Chemical Communications, 57 (47). pp. 5814-5817.


We report the design and evaluation of pH responsive luminescent europium(III) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to monitor uptake into more acidic organelles, thereby enhancing the performance of time-resolved internalisation assays that require pH monitoring in real time.

Item Type:Article
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Publisher statement:This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Date accepted:04 May 2021
Date deposited:25 August 2021
Date of first online publication:04 May 2021
Date first made open access:25 August 2021

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