Liping Zhang
Rational design of iridium–porphyrin conjugates for novel synergistic photodynamic and photothermal therapy anticancer agents
Zhang, Liping; Geng, Yun; Li, Lijuan; Tong, Xiaofan; Liu, Shi; Liu, Xingman; Su, Zhongmin; Xie, Zhigang; Zhu, Dongxia; Bryce, Martin R.
Authors
Yun Geng
Lijuan Li
Xiaofan Tong
Shi Liu
Xingman Liu
Zhongmin Su
Zhigang Xie
Dongxia Zhu
Professor Martin Bryce m.r.bryce@durham.ac.uk
Professor
Abstract
Near-infrared (NIR) emitters are important probes for biomedical applications. Nanoparticles (NPs) incorporating mono- and tetranuclear iridium(III) complexes attached to a porphyrin core have been synthesized. They possess deep-red absorbance, long-wavelength excitation (635 nm) and NIR emission (720 nm). TD-DFT calculations demonstrate that the iridium–porphyrin conjugates herein combine the respective advantages of small organic molecules and transition metal complexes as photosensitizers (PSs): (i) the conjugates retain the long-wavelength excitation and NIR emission of porphyrin itself; (ii) the conjugates possess highly effective intersystem crossing (ISC) to obtain a considerably more long-lived triplet photoexcited state. These photoexcited states do not have the usual radiative behavior of phosphorescent Ir(III) complexes, and they play a very important role in promoting the singlet oxygen (1O2) and heat generation required for photodynamic therapy (PDT) and photothermal therapy (PTT). The tetranuclear 4-Ir NPs exhibit high 1O2 generation ability, outstanding photothermal conversion efficiency (49.5%), good biocompatibility, low half-maximal inhibitory concentration (IC50) (0.057 μM), excellent photothermal imaging and synergistic PDT and PTT under 635 nm laser irradiation. To our knowledge this is the first example of iridium–porphyrin conjugates as PSs for photothermal imaging-guided synergistic PDT and PTT treatment in vivo.
Citation
Zhang, L., Geng, Y., Li, L., Tong, X., Liu, S., Liu, X., …Bryce, M. R. (2021). Rational design of iridium–porphyrin conjugates for novel synergistic photodynamic and photothermal therapy anticancer agents. Chemical Science, 12(16), 5918-5925. https://doi.org/10.1039/d1sc00126d
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 22, 2021 |
Online Publication Date | Mar 29, 2021 |
Publication Date | Apr 28, 2021 |
Deposit Date | Sep 7, 2021 |
Publicly Available Date | Sep 7, 2021 |
Journal | Chemical Science |
Print ISSN | 2041-6520 |
Electronic ISSN | 2041-6539 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 12 |
Issue | 16 |
Pages | 5918-5925 |
DOI | https://doi.org/10.1039/d1sc00126d |
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Advance online version This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.
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