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Regulation of prokaryotic adenylyl cyclases by CO2.

Hammer, A. and Hodgson, D. R. W. and Cann, M. J. (2006) 'Regulation of prokaryotic adenylyl cyclases by CO2.', Biochemical journal., 396 (2). pp. 215-218.


The Slr1991 adenylyl cyclase of the model prokaroyte Synechocystis PCC 6803 was stimulated 2-fold at 20 mM total Ci (inorganic carbon) atpH 7.5 through an increase in kcat.Adose response demonstrated an EC50 of 52.7 mMtotal Ci at pH 6.5. Slr1991 adenylyl cyclase was activated by CO2, but not by HCO3−. CO2 regulation of adenylyl cyclase was conserved in the CyaB1 adenylyl cyclase of Anabaena PCC 7120. These adenylyl cyclases represent the only identified signalling enzymes directly activated by CO2. The findings prompt an urgent reassessment of the activating carbon species for proposed HCO3−-activated adenylyl cyclases.

Item Type:Article
Keywords:Adenylyl cyclase (adenyl cyclase, Adenylate cyclase), Bicarbonate (HCO3−), cAMP, Carbon dioxide (CO2), Synechocystis.
Full text:(AM) Accepted Manuscript
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Publisher statement:This research was originally published in Biochemical journal. Hammer, A., Hodgson, D. R. W., Cann, M.J., Regulation of prokaryotic adenylyl cyclases by CO2. Biochemical journal. 2006; 396: 215-218 © the Biochemical Society
Date accepted:No date available
Date deposited:27 November 2014
Date of first online publication:June 2006
Date first made open access:No date available

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