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How good is the evidence that cellular senescence causes skin ageing?

Low, Evon; Alimohammadiha, Ghazaleh; Smith, Lucy A.; Costello, Lydia F.; Przyborski, Stefan A.; von Zglinicki, Thomas; Miwa, Satomi

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Authors

Evon Low

Ghazaleh Alimohammadiha

Dr Lucy Smith l.a.smith2@durham.ac.uk
Post Doctoral Research Associate

Lydia F. Costello

Thomas von Zglinicki

Satomi Miwa



Abstract

Skin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and secretion of bioactive molecules. Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. In case of skin, accumulation of senescence in all major compartments with ageing is well documented and might be responsible for most, if not all, the molecular changes observed during ageing. Incorporation of senescent cells into in-vitro skin models (specifically 3D full thickness models) recapitulates changes typically associated with skin ageing. However, crucial evidence is still missing. A beneficial effect of senescent cell ablation on skin ageing has so far only been shown following rather unspecific interventions or in transgenic mouse models. We conclude that evidence for cellular senescence as a relevant cause of intrinsic skin ageing is highly suggestive but not yet completely conclusive.

Citation

Low, E., Alimohammadiha, G., Smith, L. A., Costello, L. F., Przyborski, S. A., von Zglinicki, T., & Miwa, S. (2021). How good is the evidence that cellular senescence causes skin ageing?. Ageing Research Reviews, 71, https://doi.org/10.1016/j.arr.2021.101456

Journal Article Type Article
Acceptance Date Aug 31, 2021
Online Publication Date Sep 3, 2021
Publication Date 2021-11
Deposit Date Sep 8, 2021
Publicly Available Date Mar 29, 2024
Journal Ageing Research Reviews
Print ISSN 1568-1637
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 71
DOI https://doi.org/10.1016/j.arr.2021.101456

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