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Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality

Jayabhavan, Sreejith Sudhakaran and Steed, Jonathan W. and Damodaran, Krishna K. (2021) 'Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality.', Crystal Growth & Design, 21 (9). pp. 5383-5393.


A series of bis(urea) compounds with complementary functional groups similar to the pharmaceutical drug metronidazole and a structural isomer isometronidazole have been synthesized. The gelation properties of these compounds were studied in various solvent/solvent mixtures. The mechanical strength of the isomeric gelators was compared using rheology, and the morphologies of the xerogels were analyzed by scanning electron microscopy. These gels were used as media for metronidazole crystallization resulting in a marked habit modification of the metronidazole crystals in the drug-mimicking gels. However, crystallization in the nonmimetic isomeric gel resulted in morphologies similar to the solution state. These results indicate that the drug-mimetic gels interact with the surface of the drug crystal giving rise to new morphologies.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Date accepted:15 July 2021
Date deposited:28 October 2021
Date of first online publication:30 July 2021
Date first made open access:30 July 2022

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