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Early Life, Life Course and Gender Influences on Levels of C-Reactive Protein among Migrant Bangladeshis in the UK

Begum, Khurshida and Cooper, Gillian D. and Nahar, Papreen and Akhter, Nasima and Kasim, Adetayo and Bentley, Gillian R. (2022) 'Early Life, Life Course and Gender Influences on Levels of C-Reactive Protein among Migrant Bangladeshis in the UK.', Evolution, medicine, and public health., 10 (1). pp. 21-35.

Abstract

Background and objectives: Humans co-evolved with pathogens, especially helminths, that educate the immune system during development and lower inflammatory responses. Absence of such stimuli in industrialized countries is associated with higher baseline, adult levels of C-reactive protein (CRP) who appear at greater risk for inflammatory disorders. This cross-sectional study examined effects of early life development on salivary CRP levels in 452 British-Bangladeshis who spent varying periods growing up in Bangladesh or UK. We also analyzed how gender and central obesity modulate effects on CRP. We hypothesized that: (i) first-generation Bangladeshis with higher childhood exposure to pathogens would have chronically lower CRP levels than second-generation British-Bangladeshis; (ii) effects would be greater with early childhoods in Bangladesh; (iii) effects by gender would differ; and (iv) increasing obesity would mitigate early life effects. Methodology: Saliva samples were analyzed for CRP using ELISAs, and anthropometric data collected. Participants completed questionnaires about demographic, socioeconomic, lifestyle and health histories. Data were analyzed using multiple linear regression. Results: First-generation migrants who spent early childhoods in mostly rural, unhygienic areas, and moved to UK after age 8, had lower salivary CRP compared to the second-generation. Effects differed by gender, while waist circumference predicted higher CRP levels. CRP increased with years in UK, alongside growing obesity. Conclusions and implications: Our study supports the hypothesis that pathogen exposure in early life lowers inflammatory responses in adults. However, protective effects differed by gender and can be eroded by growing obesity across the life course which elevates risks for other inflammatory disorders. Lay Summary: Migrants to the UK who spent early childhoods in less hygienic environments in Bangladesh that help to educate their immune systems had lower levels of the inflammatory marker, C-reactive protein (CRP) compared to migrants who grew up in UK. Both gender and increasing obesity were associated with increased levels of CRP.

Item Type:Article
Full text:(AM) Accepted Manuscript
Available under License - Creative Commons Attribution 4.0.
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.1093/emph/eoab041
Publisher statement:© The Author(s) 2021. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Date accepted:18 November 2021
Date deposited:29 November 2021
Date of first online publication:27 November 2021
Date first made open access:29 November 2021

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