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Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer

von Grabowiecki, Yanncik and Phatak, Vinaya and Aschauer, Lydia and Muller, Patricia AJ (2021) 'Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer.', Frontiers in Oncology, 11 . p. 804107.

Abstract

Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins.

Item Type:Article
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Status:Peer-reviewed
Publisher Web site:https://doi.org/10.3389/fonc.2021.804107
Publisher statement:Copyright © 2021 von Grabowiecki, Phatak, Aschauer and Muller. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Date accepted:03 December 2021
Date deposited:16 December 2021
Date of first online publication:21 December 2021
Date first made open access:16 December 2021

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