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Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro

Costello, Lydia and Dicolandrea, Teresa and Tasseff, Ryan and Isfort, Robert and Bascom, Charlie and von Zglinicki, Thomas and Przyborski, Stefan (2022) 'Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro.', Aging Cell, 21 (2). e13550.


Human skin ageing is a complex and heterogeneous process, which is influenced by genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic stressors. In the current world ageing demographic, there is a requirement for a bioengineered ageing skin model, to further the understanding of the intricate molecular mechanisms of skin ageing, and provide a distinct and biologically relevant platform for testing actives and formulations. There have been many recent advances in the development of skin models that recapitulate aspects of the ageing phenotype in vitro. This review encompasses the features of skin ageing, the molecular mechanisms that drive the ageing phenotype, and tissue engineering strategies that have been utilised to bioengineer ageing skin in vitro.

Item Type:Article
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Publisher statement:© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Date accepted:29 December 2021
Date deposited:18 January 2022
Date of first online publication:17 January 2022
Date first made open access:18 January 2022

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