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Epithelial Stem Cells: Making, Shaping and Breaking the Niche

Ferraces-Riegas, Paula and Galbraith, Anona C. and Doupé, David P. (2022) 'Epithelial Stem Cells: Making, Shaping and Breaking the Niche.', in Advances in Experimental Medicine and Biology. Cham: Springer. Advances in Experimental Medicine and Biology.


Epithelial stem cells maintain tissues throughout adult life and are tightly regulated by their microenvironmental niche to balance cell production and loss. These stem cells have been studied extensively as signal-receiving cells, responding to cues from other cell types and mechanical stimuli that comprise the niche. However, studies from a wide range of systems have identified epithelial stem cells as major contributors to their own microenvironment either through producing niche cells, acting directly as niche cells or regulating niche cells. The importance of stem cell contributions to the niche is particularly clear in cancer, where tumour cells extensively remodel their microenvironment to promote their survival and proliferation.

Item Type:Book chapter
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Publisher statement:Open Access. This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Date accepted:No date available
Date deposited:27 January 2022
Date of first online publication:19 January 2022
Date first made open access:27 January 2022

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