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Particle detection and tracking with DNA

O’Hare, Ciaran A.J.; Matsos, Vassili G.; Newton, Joseph; Smith, Karl; Hochstetter, Joel; Jaiswar, Ravi; Kyaw, Wunna; McNamara, Aimee; Kuncic, Zdenka; Grellscheid, Sushma Nagaraja; Bœhm, Céline

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Authors

Ciaran A.J. O’Hare

Vassili G. Matsos

Joseph Newton

Karl Smith

Joel Hochstetter

Ravi Jaiswar

Wunna Kyaw

Aimee McNamara

Zdenka Kuncic

Céline Bœhm



Abstract

We present the first proof-of-concept simulations of detectors using biomaterials to detect particle interactions. The essential idea behind a “DNA detector” involves the attachment of a forest of precisely-sequenced single or double-stranded nucleic acids from a thin holding layer made of a high-density material. Incoming particles break a series of strands along a roughly co-linear chain of interaction sites and the severed segments then fall to a collection area. Since the sequences of base pairs in nucleic acid molecules can be precisely amplified and measured using polymerase chain reaction (PCR), the original spatial position of each broken strand inside the detector can be reconstructed with nm precision. Motivated by the potential use as a low-energy directional particle tracker, we perform the first Monte Carlo simulations of particle interactions inside a DNA detector. We compare the track topology as a function of incoming direction, energy, and particle type for a range of ionising particles. While particle identification and energy reconstruction might be challenging without a significant scale-up, the excellent potential angular and spatial resolution ( 25◦ axial resolution for keV-scale particles and nm-scale track segments) are clear advantages of this concept. We conclude that a DNA detector could be a cost-effective, portable, and powerful new particle detection technology. We outline the outstanding experimental challenges, and suggest directions for future laboratory tests.

Citation

O’Hare, C. A., Matsos, V. G., Newton, J., Smith, K., Hochstetter, J., Jaiswar, R., …Bœhm, C. (2022). Particle detection and tracking with DNA. The European Physical Journal C, 82(4), Article 306. https://doi.org/10.1140/epjc/s10052-022-10264-6

Journal Article Type Article
Acceptance Date Mar 28, 2022
Online Publication Date Apr 8, 2022
Publication Date 2022-04
Deposit Date Jul 6, 2022
Publicly Available Date Jul 6, 2022
Journal The European Physical Journal C
Print ISSN 1434-6044
Publisher SpringerOpen
Peer Reviewed Peer Reviewed
Volume 82
Issue 4
Article Number 306
DOI https://doi.org/10.1140/epjc/s10052-022-10264-6

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.





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