AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

Liu, Shengnan; Han, Jiahong; Chang, Yulei; Wang, Weijin; Wang, Runlin; Wang, Ziwei; Li, Guangzhe; Zhu, Dongxia; Bryce, Martin R.

doi:10.1039/d2cc03622c

AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

Liu, Shengnan; Han, Jiahong; Chang, Yulei; Wang, Weijin; Wang, Runlin; Wang, Ziwei; Li, Guangzhe; Zhu, Dongxia; Bryce, Martin R.

Authors

Shengnan Liu

Jiahong Han

Yulei Chang

Weijin Wang

Runlin Wang

Ziwei Wang

Guangzhe Li

Dongxia Zhu

Professor Martin Bryce m.r.bryce@durham.ac.uk
Professor

Abstract

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high 1O2 generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.

Citation

Liu, S., Han, J., Chang, Y., Wang, W., Wang, R., Wang, Z., …Bryce, M. R. (2022). AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy. Chemical Communications, 58(72), 10056 - 10059. https://doi.org/10.1039/d2cc03622c

Journal Article Type	Article
Acceptance Date	Aug 11, 2022
Online Publication Date	Aug 22, 2022
Publication Date	2022
Deposit Date	Sep 15, 2022
Publicly Available Date	Sep 15, 2022
Journal	Chemical Communications
Print ISSN	1359-7345
Electronic ISSN	1364-548X
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	58
Issue	72
Pages	10056 - 10059
DOI	https://doi.org/10.1039/d2cc03622c