We use cookies to ensure that we give you the best experience on our website. By continuing to browse this repository, you give consent for essential cookies to be used. You can read more about our Privacy and Cookie Policy.

Durham Research Online
You are in:

Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety

Tataridas-Pallas, Nikolaos and Thompson, Maximillian A. and Howard, Alexander and Brown, Ian and Ezcurra, Marina and Wu, Ziyun and Silva, Isabel Goncalves and Saunter, Christopher D. and Kuerten, Timo and Weinkove, David and Blackwell, T. Keith and Tullet, Jennifer M. A. (2021) 'Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.', PLOS Genetics, 17 (3). e1009358.


The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.

Item Type:Article
Full text:(VoR) Version of Record
Available under License - Creative Commons Attribution 4.0.
Download PDF
Publisher Web site:
Publisher statement:© 2021 Tataridas-Pallas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Date accepted:17 January 2021
Date deposited:24 October 2022
Date of first online publication:04 March 2021
Date first made open access:24 October 2022

Save or Share this output

Look up in GoogleScholar