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Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders

Oertel, Frederike Cosima; Zimmermann, Hanna G; Motamedi, Seyedamirhosein; Chien, Claudia; Aktas, Orhan; Albrecht, Philipp; Ringelstein, Marius; Dcunha, Anitha; Pandit, Lekha; Martinez-Lapiscina, Elena H; Sanchez-Dalmau, Bernardo; Villoslada, Pablo; Palace, Jacqueline; Roca-Fernández, Adriana; Leite, Maria Isabel; Sharma, Srilakshmi M; Leocani, Letizia; Pisa, Marco; Radaelli, Marta; Lana-Peixoto, Marco Aurélio; Fontenelle, Mariana Andrade; Havla, Joachim; Ashtari, Fereshteh; Kafieh, Rahele; Dehghani, Alireza; Pourazizi, Mohsen; Marignier, Romain; Cobo-Calvo, Alvaro; Asgari, Nasrin; Jacob, Anu; Huda, Saif; Mao-Draayer, Yang; Green, Ari J; Kenney, Rachel; Yeaman, Michael R; Smith, Terry J; Cook, Lawrence; Brandt, Alexander U; Paul, Friedemann; Petzold, Axel

Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders Thumbnail


Authors

Frederike Cosima Oertel

Hanna G Zimmermann

Seyedamirhosein Motamedi

Claudia Chien

Orhan Aktas

Philipp Albrecht

Marius Ringelstein

Anitha Dcunha

Lekha Pandit

Elena H Martinez-Lapiscina

Bernardo Sanchez-Dalmau

Pablo Villoslada

Jacqueline Palace

Adriana Roca-Fernández

Maria Isabel Leite

Srilakshmi M Sharma

Letizia Leocani

Marco Pisa

Marta Radaelli

Marco Aurélio Lana-Peixoto

Mariana Andrade Fontenelle

Joachim Havla

Fereshteh Ashtari

Alireza Dehghani

Mohsen Pourazizi

Romain Marignier

Alvaro Cobo-Calvo

Nasrin Asgari

Anu Jacob

Saif Huda

Yang Mao-Draayer

Ari J Green

Rachel Kenney

Michael R Yeaman

Terry J Smith

Lawrence Cook

Alexander U Brandt

Friedemann Paul

Axel Petzold



Abstract

Background: The novel optic neuritis (ON) diagnostic criteria include intereye differences (IED) of optical coherence tomography (OCT) parameters. IED has proven valuable for ON diagnosis in multiple sclerosis but has not been evaluated in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders (AQP4+NMOSD). We evaluated the diagnostic accuracy of intereye absolute (IEAD) and percentage difference (IEPD) in AQP4+NMOSD after unilateral ON >6 months before OCT as compared with healthy controls (HC). Methods: Twenty-eight AQP4+NMOSD after unilateral ON (NMOSD-ON), 62 HC and 45 AQP4+NMOSD without ON history (NMOSD-NON) were recruited by 13 centres as part of the international Collaborative Retrospective Study on retinal OCT in Neuromyelitis Optica study. Mean thickness of peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (GCIPL) were quantified by Spectralis spectral domain OCT. Threshold values of the ON diagnostic criteria (pRNFL: IEAD 5 µm, IEPD 5%; GCIPL: IEAD: 4 µm, IEPD: 4%) were evaluated using receiver operating characteristics and area under the curve (AUC) metrics. Results: The discriminative power was high for NMOSD-ON versus HC for IEAD (pRNFL: AUC 0.95, specificity 82%, sensitivity 86%; GCIPL: AUC 0.93, specificity 98%, sensitivity 75%) and IEPD (pRNFL: AUC 0.96, specificity 87%, sensitivity 89%; GCIPL: AUC 0.94, specificity 96%, sensitivity 82%). The discriminative power was high/moderate for NMOSD-ON versus NMOSD-NON for IEAD (pRNFL: AUC 0.92, specificity 77%, sensitivity 86%; GCIP: AUC 0.87, specificity 85%, sensitivity 75%) and for IEPD (pRNFL: AUC 0.94, specificity 82%, sensitivity 89%; GCIP: AUC 0.88, specificity 82%, sensitivity 82%). Conclusions: Results support the validation of the IED metrics as OCT parameters of the novel diagnostic ON criteria in AQP4+NMOSD.

Citation

Oertel, F. C., Zimmermann, H. G., Motamedi, S., Chien, C., Aktas, O., Albrecht, P., …Petzold, A. (2023). Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders. Journal of Neurology, Neurosurgery and Psychiatry, 94(7), 560-566. https://doi.org/10.1136/jnnp-2022-330608

Journal Article Type Article
Acceptance Date Feb 9, 2023
Online Publication Date Feb 21, 2023
Publication Date Jun 14, 2023
Deposit Date Mar 3, 2023
Publicly Available Date Mar 3, 2023
Journal Journal of Neurology, Neurosurgery & Psychiatry
Print ISSN 0022-3050
Electronic ISSN 1468-330X
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 94
Issue 7
Pages 560-566
DOI https://doi.org/10.1136/jnnp-2022-330608
Public URL https://durham-repository.worktribe.com/output/1177812

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Publisher Licence URL
http://creativecommons.org/licenses/by-nc/4.0/

Copyright Statement
Online First © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.





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