Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

Estrach, S.; Ambler, C.A.; Lo Celso, C.; Hozumi, K.; Watt, F.M.

doi:10.1242/dev.02644

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

Estrach, S.; Ambler, C.A.; Lo Celso, C.; Hozumi, K.; Watt, F.M.

Authors

S. Estrach

Professor Carrie Ambler c.a.ambler@durham.ac.uk
Professor

C. Lo Celso

K. Hozumi

F.M. Watt

Abstract

The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing interfollicular epidermal differentiation. Conversely, activation of Notch in adult epidermis triggers expansion of the base of the hair follicle, sebaceous gland enlargement and abnormal clumping of the follicles. In adult epidermis, the induction of new hair follicle formation by beta-catenin is prevented by blocking Notch signalling pharmacologically or through Jag1 deletion. Conversely, activation of both pathways accelerates growth and differentiation of ectopic follicles. beta-catenin stimulates Notch signalling by inducing Jag1 transcription. We conclude that the Notch pathway acts downstream of the Wnt/beta-catenin pathway to determine epidermal cell fate.

Citation

Estrach, S., Ambler, C., Lo Celso, C., Hozumi, K., & Watt, F. (2006). Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development, 133(22), 4427-4438. https://doi.org/10.1242/dev.02644

Journal Article Type	Article
Acceptance Date	Sep 14, 2006
Online Publication Date	Oct 30, 2006
Publication Date	Nov 15, 2006
Deposit Date	Jan 17, 2008
Publicly Available Date	May 11, 2018
Journal	Development.
Print ISSN	0950-1991
Electronic ISSN	1477-9129
Publisher	The Company of Biologists
Peer Reviewed	Peer Reviewed
Volume	133
Issue	22
Pages	4427-4438
DOI	https://doi.org/10.1242/dev.02644
Keywords	Beta-catenin, Notch, Jagged 1, Epidermis, Mouse.