Jones, P. M. and Pearce, J. M. and Davies, V. J. and Good, M. A. and McGregor, A. (2007) 'Impaired processing of local geometric features during navigation in a water maze following hippocampal lesions in rats.', Behavioural neuroscience., 121 (6). pp. 1258-1271.
Hippocampal damage impairs navigation with respect to information provided by the shape of an arena. Recent evidence has suggested that normal rats use local geometric information, as opposed to a global geometric representation, to navigate to a correct corner. One implication of this pattern of results is that hippocampal lesions may impair processing of 1 or more of the local geometric features of an environment. The authors therefore investigated the effects of hippocampal cell loss in rats on navigation to a hidden goal with respect to a variety of local cues in an environment with a distinctive shape. Rats with lesions of the hippocampus were impaired in discriminating a right-angled corner from its mirror image. However, they were able to use cues provided by an acute-angled corner (Experiment 1) or a local polarizing cue (Experiment 2). In contrast, lesioned rats were impaired in discriminating long versus short walls (Experiment 3). Results indicate that the hippocampus plays a role in disambiguating locations by processing (metric) information related to the distance between corners.
|Keywords:||Spatial learning, Water maze, Geometry, Hippocampus, Navigation.|
|Full text:||Full text not available from this repository.|
|Publisher Web site:||http://dx.doi.org/10.1037/0735-7044.121.6.1258|
|Date accepted:||No date available|
|Date deposited:||No date available|
|Date of first online publication:||December 2007|
|Date first made open access:||No date available|
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