Skip to main content

Research Repository

Advanced Search

Evolution of Neurologic Features in Williams Syndrome

Gagliardi, Chiara; Martelli, Sara; Burt, D. Michael; Borgatti, Renato

Authors

Chiara Gagliardi

Sara Martelli

Renato Borgatti



Abstract

As a part of a large multidisciplinary clinical and research follow-up study, 47 Williams syndrome patients underwent detailed neurologic testing. Because previous studies have documented the absence of major neurologic signs in Williams syndrome, the neurologic testing focused on soft signs. Previous findings of impairment of both gross and fine motor coordination were confirmed, and the presence of mild cerebellar and extrapyramidal signs was documented. In a 4-year follow-up study, an age-related pattern was revealed: soft extrapyramidal signs became more evident from 8 years of age and increased in the 14 year age group. The results are discussed according to a hypothesis related to the dopaminergic system involvement in Williams syndrome: anomalous organization or accelerated ageing process.

Citation

Gagliardi, C., Martelli, S., Burt, D. M., & Borgatti, R. (2007). Evolution of Neurologic Features in Williams Syndrome. Pediatric Neurology, 36(5), 301-306. https://doi.org/10.1016/j.pediatrneurol.2007.01.001

Journal Article Type Article
Publication Date May 1, 2007
Deposit Date Nov 2, 2009
Journal Pediatric Neurology
Print ISSN 0887-8994
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 36
Issue 5
Pages 301-306
DOI https://doi.org/10.1016/j.pediatrneurol.2007.01.001


You might also like



Downloadable Citations