A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx

Jackson, T.J.; Sanderson, J.M.; Kataky, R.

doi:10.1016/j.snb.2007.10.019

A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx

Jackson, T.J.; Sanderson, J.M.; Kataky, R.

Authors

T.J. Jackson

Dr John Sanderson j.m.sanderson@durham.ac.uk
Associate Professor

Professor Ritu Kataky ritu.kataky@durham.ac.uk
Professor

Abstract

A synthetic analogue of gramicidin A, gram-2-(nicotinamidyl)ethyl carbamate (gAN) was found to regulate the influx of potassium ions depending on its redox state. At potentials less than −0.52 (±0.05) V, the nicotinamide group in gAN is reduced and allows charge- and size-selective influx of cations. In the oxidised state, charge repulsion between the positively charged nicotinamide group and the cations prevents any influx of cations. Chronoamperometric experiments were conducted to determine permeabilities of Eu3+, Tl+, K+ ions in a BLM porated with gAN. Scanning electrochemical microscopy (SECM) experiments were conducted with two ions: permeant K+ ions and the larger (CH3)4N+ ion which blocks the channel. The switching potential for gAN, at which the channel allows flux monovalent cations, is shown to be potential and pH-dependent and temperature-independent.

Citation

Jackson, T., Sanderson, J., & Kataky, R. (2008). A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx. Sensors and Actuators B: Chemical, 130(2), 630-637. https://doi.org/10.1016/j.snb.2007.10.019

Journal Article Type	Article
Acceptance Date	Oct 16, 2007
Online Publication Date	Oct 23, 2007
Publication Date	Mar 28, 2008
Deposit Date	Jun 21, 2011
Publicly Available Date	Jan 3, 2012
Journal	Sensors and Actuators B: Chemical
Print ISSN	0925-4005
Publisher	Elsevier
Peer Reviewed	Not Peer Reviewed
Volume	130
Issue	2
Pages	630-637
DOI	https://doi.org/10.1016/j.snb.2007.10.019