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Sphingolipid and ceramide homeostasis, potential therapeutic targets

Young, S.A.; Mina, J.G.; Denny, P.W.; Smith, T.K.

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Authors

S.A. Young

T.K. Smith



Abstract

Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these processes for therapies against cancers, Alzheimer's disease, and numerous important human pathogens. In this paper we outline the major pathways in eukaryotic sphingolipid metabolism and discuss these in relation to disease and therapy for both chronic and infectious conditions.

Citation

Young, S., Mina, J., Denny, P., & Smith, T. (2012). Sphingolipid and ceramide homeostasis, potential therapeutic targets. Biochemistry Research International, 2012, Article 248135. https://doi.org/10.1155/2012/248135

Journal Article Type Article
Publication Date Jan 1, 2012
Deposit Date Oct 21, 2011
Publicly Available Date Mar 28, 2024
Journal Biochemistry Research International
Print ISSN 2090-2247
Electronic ISSN 2090-2255
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2012
Article Number 248135
DOI https://doi.org/10.1155/2012/248135

Files

Published Journal Article (1.2 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright © 2012 Simon A. Young et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





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