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Durham Research Online
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Engineering eukaryotic protein factories.

Schröder, M. (2008) 'Engineering eukaryotic protein factories.', Biotechnology letters., 30 (2). pp. 187-196.


The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.

Item Type:Article
Keywords:Unfolded protein response, Endoplasmic reticulum, Molecular chaperone, Recombinant protein production, Heterologous protein production, Protein folding.
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Publisher statement:This article is published under a Creative Commons Attribution (CC-BY) license.
Date accepted:No date available
Date deposited:12 June 2012
Date of first online publication:February 2008
Date first made open access:No date available

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