Schröder, M. (2008) 'Engineering eukaryotic protein factories.', Biotechnology letters., 30 (2). pp. 187-196.
The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.
|Keywords:||Unfolded protein response, Endoplasmic reticulum, Molecular chaperone, Recombinant protein production, Heterologous protein production, Protein folding.|
|Full text:||(VoR) Version of Record|
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|Publisher Web site:||http://dx.doi.org/10.1007/s10529-007-9524-1|
|Publisher statement:||This article is published under a Creative Commons Attribution (CC-BY) license.|
|Date accepted:||No date available|
|Date deposited:||12 June 2012|
|Date of first online publication:||February 2008|
|Date first made open access:||No date available|
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