A CMOS time-resolved fluorescence lifetime analysis micro-system

Rae, Bruce; Muir, Keith R; Gong, Zheng; McKendry, Jonathan; Girkin, John M; Gu, Erdan; Renshaw, David; Dawson, Martin D; Henderson, Robert

doi:10.3390/s91109255

A CMOS time-resolved fluorescence lifetime analysis micro-system

Rae, Bruce; Muir, Keith R; Gong, Zheng; McKendry, Jonathan; Girkin, John M; Gu, Erdan; Renshaw, David; Dawson, Martin D; Henderson, Robert

Authors

Bruce Rae

Keith R Muir

Zheng Gong

Jonathan McKendry

Professor John Girkin j.m.girkin@durham.ac.uk
Professor

Erdan Gu

David Renshaw

Martin D Dawson

Robert Henderson

Abstract

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.

Citation

Rae, B., Muir, K. R., Gong, Z., McKendry, J., Girkin, J. M., Gu, E., …Henderson, R. (2009). A CMOS time-resolved fluorescence lifetime analysis micro-system. Sensors, 9(11), 9255-9274. https://doi.org/10.3390/s91109255

Journal Article Type	Article
Publication Date	Nov 1, 2009
Deposit Date	Nov 8, 2011
Publicly Available Date	Jun 8, 2012
Journal	Sensors
Publisher	MDPI
Peer Reviewed	Peer Reviewed
Volume	9
Issue	11
Pages	9255-9274
DOI	https://doi.org/10.3390/s91109255