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Estrogen therapy affects right hemispheric functioning in postmenopausal women.

Bayer, U. and Hausmann, M. (2009) 'Estrogen therapy affects right hemispheric functioning in postmenopausal women.', Hormones and behavior., 55 (1). pp. 228-234.


It has been suggested that hormone therapy (HT) in postmenopausal women differentially affects verbal and visuo-spatial abilities which mainly rely on left hemisphere (LH) and right hemisphere (RH) functioning, respectively. Thus, it seems likely that HT-related effects on cognition are driven by associated hormonal changes and their impact on functional brain organization, and functional cerebral asymmetries (FCAs) in particular. The present study investigated HT-related effects on FCAs in sixty-seven postmenopausal women who received hormone therapy either with estrogen (E) alone (n = 14), an E-gestagen combination (n = 22) or without HT (control group, n = 31). Saliva levels of free E and progesterone (P) were analyzed using chemiluminescence assays. FCAs were measured with the visual half-field (VHF) technique using a word matching and a figural comparison task. In agreement with previous results, a postmenopausal control group showed a left hemisphere (LH) advantage in the verbal task and a right hemisphere (RH) advantage in visuo-spatial processing. In contrast, both HT groups revealed significantly reduced FCAs in the figural comparison task as a result of an E-related decrease in RH performance. The findings suggest that E-therapy in postmenopausal women can affect visuo-spatial abilities by modulating the functional brain organization and RH functioning in particular.

Item Type:Article
Keywords:Hormone therapy, Estrogen, Progesterone, Postmenopausal women, Hemispheric differences, Aging.
Full text:Full text not available from this repository.
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Date accepted:No date available
Date deposited:No date available
Date of first online publication:January 2009
Date first made open access:No date available

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