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Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.

Taylor, A.M. and Niewoehner, B. and Seeburg, P.H. and Sprengel, R. and Rawlins, J.N.P. and Bannerman, D.M. and Sanderson, D.J. (2011) 'Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.', Behavioural brain research., 224 (1). pp. 8-14.


GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.

Item Type:Article
Keywords:AMPA receptors, Conditional learning, Trace conditioning, Non-spatial memory, Spatial memory.
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Available under License - Creative Commons Attribution.
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Publisher statement:© 2011 Elsevier B.V. Open access under CC BY license
Date accepted:No date available
Date deposited:24 February 2017
Date of first online publication:October 2011
Date first made open access:No date available

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