Taylor, A.M. and Niewoehner, B. and Seeburg, P.H. and Sprengel, R. and Rawlins, J.N.P. and Bannerman, D.M. and Sanderson, D.J. (2011) 'Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.', Behavioural brain research., 224 (1). pp. 8-14.
GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.
|Keywords:||AMPA receptors, Conditional learning, Trace conditioning, Non-spatial memory, Spatial memory.|
|Full text:||(VoR) Version of Record|
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|Publisher Web site:||https://doi.org/10.1016/j.bbr.2011.05.016|
|Publisher statement:||© 2011 Elsevier B.V. Open access under CC BY license|
|Date accepted:||No date available|
|Date deposited:||24 February 2017|
|Date of first online publication:||October 2011|
|Date first made open access:||No date available|
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